Abstract
A series of pyridopyrazine and pyrimidothiazine derivatives have been synthesized and their activity against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro antibacterial activity against Mtb H(37)Ra and Mtb H(37)Rv are reported. Certain analogs described herein showed moderate to good inhibitory activity.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Animals
-
Antitubercular Agents / chemical synthesis
-
Antitubercular Agents / chemistry
-
Antitubercular Agents / pharmacology*
-
Bacterial Proteins / antagonists & inhibitors*
-
Cytoskeletal Proteins / antagonists & inhibitors*
-
Disease Models, Animal
-
Humans
-
Mice
-
Mice, Inbred C57BL
-
Mycobacterium tuberculosis / chemistry
-
Mycobacterium tuberculosis / drug effects
-
Mycobacterium tuberculosis / metabolism
-
Pyrazines / chemical synthesis
-
Pyrazines / chemistry
-
Pyrazines / pharmacology*
-
Pyridines / chemical synthesis
-
Pyridines / chemistry
-
Pyridines / pharmacology
-
Pyrimidines / chemical synthesis
-
Pyrimidines / chemistry
-
Pyrimidines / pharmacology
-
Structure-Activity Relationship
-
Thiazines / chemical synthesis
-
Thiazines / chemistry
-
Thiazines / pharmacology*
Substances
-
Antitubercular Agents
-
Bacterial Proteins
-
Cytoskeletal Proteins
-
FtsZ protein, Bacteria
-
Pyrazines
-
Pyridines
-
Pyrimidines
-
Thiazines